Chiropractic care is most effective for knee pain caused by conditions such as patellofemoral pain syndrome, iliotibial band syndrome, mild meniscal irritation, early to moderate osteoarthritis, referred pain from the hip or lower back, and issues related to poor alignment or gait dysfunction. Treatment typically involves joint adjustments targeting the knee, hip, ankle, or spine, combined with soft tissue therapy, stretching and strengthening exercises, as well as postural and gait correction.